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Lithium Plus Valproate Combination versus Monotherapy for Relapse Prevention in Bipolar I Disorder (BALANCE) 

Lithium Plus Valproate Combination versus Monotherapy for Relapse Prevention in Bipolar I Disorder (BALANCE)
Chapter:
Lithium Plus Valproate Combination versus Monotherapy for Relapse Prevention in Bipolar I Disorder (BALANCE)
Author(s):

João Paulo De Aquino

, and Robert Beech

DOI:
10.1093/med/9780190625085.003.0003
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date: 18 September 2020

This chapter provides a summary of a landmark study on bipolar disorder. It starts by describing the overarching goal of this clinical trial, which was to address the following question: Is lithium plus valproate better than monotherapy with either drug alone for relapse prevention in bipolar I disorder? Subsequently, the describes basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations are described and discussed. Finally, other relevant studies and information are reviewed, and clinical implications are examined. The chapter is concluded by reviewing a relevant clinical case.

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