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Exposure and Ritual Prevention, Clomipramine, or Their Combination for Obsessive-Compulsive Disorder 

Exposure and Ritual Prevention, Clomipramine, or Their Combination for Obsessive-Compulsive Disorder
Chapter:
Exposure and Ritual Prevention, Clomipramine, or Their Combination for Obsessive-Compulsive Disorder
Author(s):

Brandon M. Kitay

, and Michael H. Bloch

DOI:
10.1093/med/9780190625085.003.0029
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date: 23 October 2019

This chapter provides a summary of a landmark study on the management of obsessive-compulsive disorder (OCD) in adults. Is the combination of exposure and ritual prevention (a cognitive behavior therapy based intervention) along with clomipramine more efficacious than monotherapy with either treatment for OCD? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study interventions, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications for clinical management, and concludes with an exemplary clinical case applying the evidence.

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