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Sequenced Treatment Alternatives to Relieve Depression: STAR*D 

Sequenced Treatment Alternatives to Relieve Depression: STAR*D
Sequenced Treatment Alternatives to Relieve Depression: STAR*D

Eric Lin

, and Pochu Ho

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date: 18 September 2020

This chapter provides a summary of the landmark Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial on major depressive disorder. The STAR*D trial was designed to address some basic questions about depression treatment. What are the outcomes and the remission rates for depression? What are the long-term outcomes, especially the relapse rates, for patients receiving sequential depression therapies? Starting with these questions, this chapter describes the basics of the STAR*D trial, including funding, study location, study population, number of study participants, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. In addition, this chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.

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