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National Institute of Mental Health (NIMH) Treatment of Depression Collaborative Research Program 

National Institute of Mental Health (NIMH) Treatment of Depression Collaborative Research Program
Chapter:
National Institute of Mental Health (NIMH) Treatment of Depression Collaborative Research Program
Author(s):

Joseph J. Taylor

, and Robert Ostroff

DOI:
10.1093/med/9780190625085.003.0024
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date: 23 October 2019

This chapter will summarize what is considered to be the first randomized controlled trial to directly compare psychotherapeutic and psychopharmacological interventions for unipolar nonpsychotic depression. More specifically, the authors were interested in the degree to which cognitive behavioral therapy, interpersonal therapy, imipramine and a placebo condition ameliorated symptoms of depression in patients from outpatient psychiatric clinics at three academic medical centers in the United States. The chapter will discuss the design and implementation of the study before focusing on the results and their implications. The last section of the chapter will list similar studies and present a hypothetical clinical case that requires the reader to apply basic concepts learned from the study.

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