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Wakeful Unresponsiveness 

Wakeful Unresponsiveness
Wakeful Unresponsiveness

Susan H. Fox

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date: 15 April 2021

NMDA receptor encephalitis is a member of the growing group of antibody-mediated neurological syndromes that can present acutely to neurological services. In the past, these entities were undoubtedly misdiagnoses as viral encephalitis or schizophrenia. The identification of the NMDA receptor antibody and a stereotypical phenotype has greatly improved the chance of a diagnosis in these patients. Furthermore, there is good evidence for the use of early immunotherapy, which may need to be sustained and increased in resistant cases that may still achieve a full recovery. The presence of an ovarian teratoma must be excluded in young females, although young males and females may also be affected in the absence of an underlying tumor.

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