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Human Papillomavirus 

Human Papillomavirus
Human Papillomavirus

Shelly Ben-Harush Negari

and Jessica A. Kahn

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date: 01 March 2021

Human papillomavirus (HPV) is a ubiquitous, single-stranded DNA virus that is commonly sexually transmitted and an important cause of cervical cancer. Manifestations of infection in the perinatal and childhood periods are recurrent respiratory papillomatosis (RRP) and anogenital warts (AGWs). Children with respiratory papillomatosis most commonly develop papillomas in the larynx, but papillomas may develop in any location along the respiratory tract. Although RRP is rare, it is the most common benign neoplasm of the larynx among children and the second-most-frequent cause of childhood hoarseness. AGWs are uncommon in the perinatal period and typically benign. They may develop on the vulva, hymen, vagina, urethra, or perianal area in girls and on the perianal area in boys. The clinical manifestations, epidemiology, diagnostic studies, and management strategies pertinent to these infections are reviewed.

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