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Anti-Inflammatory Effects of a Ketogenic Diet: Implications for New Indications 

Anti-Inflammatory Effects of a Ketogenic Diet: Implications for New Indications
Chapter:
Anti-Inflammatory Effects of a Ketogenic Diet: Implications for New Indications
Author(s):

Nina Dupuis

, and Stéphane Auvin

DOI:
10.1093/med/9780190497996.003.0017
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date: 06 August 2020

The high-fat, low-carbohydrate ketogenic diet (KD) is an established and proven treatment for pharmacoresistant epilepsy. Recently, the KD is being explored for some inflammation-induced epileptic encephalopathies. Given the broad neuroprotective properties of the KD in various experimental models of neurological disorders, there are yet additional potential future uses. Consistent with this, there is growing evidence that the KD exerts anti-inflammatory activity. Ketone bodies, caloric restriction, and polyunsaturated fatty acids might be involved in the modulation of inflammation by the KD. This chapter reviews the evidence that, in part through anti-inflammatory effects, the KD holds promise in the treatment of certain epileptic disorders, neuropathic pain, multiple sclerosis, and Parkinson’s disease.

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