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Initiation of Antiretroviral Therapy: What to Start With 

Initiation of Antiretroviral Therapy: What to Start With
Initiation of Antiretroviral Therapy: What to Start With

Saira Ajmal

and Zelalem Temesgen

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date: 29 October 2020

The primary goal of therapy is to prevent HIV-associated morbidity and mortality. In addition to the dramatic decline in HIV-related illness and death that has been observed as a result of the introduction and expansion of combination antiretroviral therapy, evidence is emerging that uncontrolled HIV replication also has a deleterious impact on conditions that are not conventionally associated with immune deficiency. These conditions include cardiovascular disease, kidney disease, liver disease, neurologic complications, and malignancy. Studies have found an independent association between cumulative exposure to replicating virus over time and mortality. Emerging data also increasingly support the earlier use of ART.

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