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A 2-Month-Old Boy with Acute Diffuse Weakness 

A 2-Month-Old Boy with Acute Diffuse Weakness
Chapter:
A 2-Month-Old Boy with Acute Diffuse Weakness
Author(s):

Jeffrey A. Cohen

, Justin J. Mowchun

, Victoria H. Lawson

, and Nathaniel M. Robbins

DOI:
10.1093/med/9780190491901.003.0034
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date: 26 January 2021

An infant presenting with acute weakness is an alarming problem that requires urgent diagnosis and action. Acute inflammatory demyelinating polyradiculoneuropathy is always a consideration, but botulism is important to remember. We discuss the key clinical signs that distinguish botulism from other causes of acute weakness, including pupillary and gastrointestinal dysfunction. We review the various forms of botulism and the known epidemiology. Botulism-related neuromuscular junction pathophysiology is reviewed. We discuss treatment and stress that supportive modalities and BIG-IV should be instituted early. We discuss prognosis and reinforce that despite the condition's seriousness, prognosis is good with prompt recognition and treatment.

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