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A 28-Year-Old Male with Weakness in the Setting of Cancer 

A 28-Year-Old Male with Weakness in the Setting of Cancer
Chapter:
A 28-Year-Old Male with Weakness in the Setting of Cancer
Author(s):

Jeffrey A. Cohen

, Justin J. Mowchun

, Victoria H. Lawson

, and Nathaniel M. Robbins

DOI:
10.1093/med/9780190491901.003.0016
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date: 26 January 2021

Chemotherapy-induced peripheral neuropathy is a common complication of cancer therapy. The diagnosis is generally straightforward, based on the temporal association of symptoms with the offending agent. However, it can sometimes take on a different form of severe, fulminant neuropathy and must be differentiated from other neurologic conditions that occur in the setting of cancer. Particular care must be taken in the patient with clinical indicators of longstanding, hereditary neuropathy as these can confer a distinctive susceptibility to neurotoxicity. The diagnosis relies on an index of suspicion and the exclusion of mimics of toxic neuropathy. The most important and common agents responsible for toxic neuropathy and their range of effects on nerve are discussed.

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