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Contents
- Front Matter
- Section 1 Neurologic, Sedation, and Analgesia
- 1 Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest: The HACA Trial Ala Nozari
- 2 Decompressive Craniectomy in Diffuse Traumatic Brain Injury: The DECRA Trial Merrick E. Miles and Avinash B. Kumar
- 3 Daily Interruption of Sedative Infusions in Critically Ill Patients Undergoing Mechanical Ventilation David Stahl
- 4 A Comparison of Four Treatments for Generalized Convulsive Status Epilepticus Jason L. Sanders and Jarone Lee
- 5 Efficacy and Safety of a Paired Sedation and Ventilator Weaning Protocol for Mechanically Ventilated Patients in Intensive Care: A Randomized Controlled Trial (The ABC Trial) Jeffery Katz and Steve Greenberg
- 6 A Protocol of No Sedation for Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Trial Ulrich Schmidt and Zeb McMillan
- 7 Intracranial Pressure Monitoring in Severe Traumatic Brain Injury Thomas Peponis and David R. King
- Section 2 Cardiovascular, Resuscitation, Shock
- 8 Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock: The EGDT Trial Namita Jayaprakash and Joseph Hyder
- 9 Lactate Clearance versus Central Venous Oxygen Saturation as Goals of Early Sepsis Therapy Marc de Moya and Leandra Krowsoski
- 10 Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis: The PROWESS Study Anna M. Ward and Richard M. Pino
- 11 Saline versus Albumin for Resuscitation of Critically Ill Adults: The SAFE Study Craig S. Jabaley
- 12 The Use of the Pulmonary Artery Catheter in Critical Care: The PAC-Man Trial Shahzad Shaefi and Ameeka Pannu
- 13 Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock: The VASST Karim Fikry
- 14 Comparison of Dopamine and Norepinephrine in the Treatment of Shock: The SOAP II Trial Daniel W. Johnson
- 15 CPR with Chest Compression Alone or with Rescue Breathing Christopher “Kit” Tainter and Gabriel Wardi
- 16 Advanced Heart Failure Treated with Continuous-Flow Left Ventricular Assist Device David M. Dudzinski and James Sawalla Guseh
- 17 Intraaortic Balloon Support in Myocardial Infarction Complicated by Cardiogenic Shock Samuel Bernard and David M. Dudzinski
- 18 Angioplasty versus Fibrinolytics in Acute ST-Elevation Myocardial Infarction: The DANAMI-2 Trial Bryan Simmons
- Section 3 Pulmonary, ARDS
- 19 The Acute Respiratory Distress Syndrome Network: Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome Laleh Jalilian and Jeanine Wiener-Kronish
- 20 Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome Duncan McLean and Matthias Eikermann
- 21 Prone Positioning in Severe Acute Respiratory Distress Syndrome: The PROSEVA Trial Andrea Coppadoro and Guiseppe Foti
- 22 Efficacy and Economic Assessment of Conventional Ventilatory Support versus Extracorporeal Membrane Oxygenation for Severe Adult Respiratory Failure (CESAR): A Multicentre Randomized Controlled Trial Matthew Sigakis
- 23 Comparison of Two Fluid-Management Strategies in Acute Lung Injury: The FACTT Trial Ross Gaudet and Rebecca Kalman
- 24 Positive End-Expiratory Pressure Setting in Adults with ALI and ARDS: The ExPress Trial J. Aaron Scott and Vivek Moitra
- 25 Efficacy and Safety of Corticosteroids for Persistent Acute Respiratory Distress Syndrome Sean Levy and Ednan Bajwa
- 26 Effect of Early versus Late Tracheostomy Placement on Survival in Patients Receiving Mechanical Ventilation: The TracMan Trial J. Michael Guthrie and Vadim Gudzenko
- 27 Using Esophageal Pressures to Improve Oxygenation and Compliance in Acute Lung Injury Connie Wang and Edward Bittner
- 28 A Comparison of Four Methods of Weaning Patients from Mechanical Ventilation Sheri Berg and Archit Sharma
- 29 Noninvasive Ventilation for Acute COPD Exacerbations Robert Loflin and David Kaufman
- 30 High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome Susan R. Wilcox and Haitham S. Al Ashry
- Section 4 Gastrointestinal/Nutrition
- 31 Risk Factors for Gastrointestinal Bleeding in Critically Ill Patients Miguel Cobas and Melissa Grillo
- 32 Early versus Late Parenteral Nutrition in the ICU: The EPaNIC (Early Parenteral Nutrition Completing Enteral Nutrition in Adult Critically Ill Patients) Trial D. Dante Yeh
- 33 Initial Trophic versus Full Enteral Feeding in Patients with Acute Lung Injury: The EDEN Randomized Trial Milad Sharifpour and Pedro Mendez-Tellez
- 34 Early versus On-Demand Nasoenteric Tube Feeding in Acute Pancreatitis Peter J. Fagenholz
- 35 Glutamine and Antioxidants in Critically Ill Patients: The REDOXS Trial Yuk Ming Liu and Jarone Lee
- Section 5 Renal
- 36 Low-Dose Dopamine in Patients with Early Renal Dysfunction Tao Shen
- 37 Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury Eric Ehieli and Yuriy Bronshteyn
- 38 Continuous Venovenous Hemodiafiltration versus Intermittent Hemodialysis for Acute Renal Failure in Patients with Multiple-Organ Dysfunction Syndrome: A Multicenter Randomized Trial Christina Anne Jelly and Edward Bittner
- Section 6 Hematologic
- 39 A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care: The Transfusion Requirements in Critical Care (TRICC) Trial Joseph R. Guenzer and Andrew Vardanian
- 40 Reducing Mortality Among Bleeding Trauma Patients with Tranexamic Acid: The CRASH-2 (Clinical Randomization of an Antifibrinolytic in Significant Hemorrhage-2) Randomized Controlled Trial Haytham M. A. Kaafarani
- 41 Transfusion of plasma, platelets, and Red Blood Cells in a 1:1:1 versus a 1:1:2 Ration and Mortality in Patients with Severe Trauma: The PROPPR Randomized Clinical Trial Yuk Ming Liu and Kathryn Butler
- Section 7 Infectious
- 42 Comparison of 8 versus 15 Days of Antibiotic Therapy for Ventilator-Associated Pneumonia in Adults: A Randomized Trial Laurie O. Mark and Jean Kwo
- 43 Bronchoscopy with Bronchoalveolar Lavage versus Endotracheal Aspiration for the Diagnosis of Ventilator-Associated Pneumonia Samad Rasul and David C. Kaufman
- 44 Randomized Trial of Combination versus Monotherapy for the Empiric Treatment of Suspected Ventilator-Associated Pneumonia Kimberly Pollock and Angela Meier
- 45 Use of Procalcitonin to Reduce Patients’ Exposure to Antibiotics in Intensive Care Units (PRORATA Trial): A Multicenter Randomized Controlled Trial Alice Gallo De Moraes and Dante Schiavo
- 46 Nasopharyngeal and Oropharyngeal Decontamination to Prevent Nosocomial Infection in Cardiac Surgery Patients Jose L. Diaz-Gomez and Sarah W. Robison
- 47 An Intervention to Decrease Catheter-Related Bloodstream Infections in the ICU: The Keystone ICU Project Courtney Maxey-Jones and Edward Bittner
- Section 8 Endocrine
- 48 The Normoglycemia in Intensive Care Evaluation: Survival Using Glucose Algorithm Regulation (NICE-SUGAR) Trial Daniel J. Niven and Henry T. Stelfox
- 49 Hydrocortisone Therapy for Patients with Septic Shock: The CORTICUS Trial Ryan J. Horvath and Edward Bittner
- Section 9 Musculoskeletal
- 50 Daily Interruption of Sedation with Physical and Occupational Therapy in Mechanically Ventilated Patients Michael Wolfe and Daniel Saddawi-Konefka
- End Matter