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Musculoskeletal Disorders 

Musculoskeletal Disorders
Chapter:
Musculoskeletal Disorders
Author(s):

Arya B. Mohabbat

and Christopher M. Wittich

DOI:
10.1093/med/9780190464868.003.0078
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date: 19 October 2019

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease of unknown cause that affects multiple organ systems. Disease susceptibility is conferred by an interaction between genetics, aberrant immunologic mechanisms, hormonal influences, and environmental factors. SLE has a wide range of heterogeneous clinical manifestations and is characterized by disease flares and remissions. There is a broad spectrum of disease severity, leading to significant morbidity and increased mortality.

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