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Acute Kidney Injury 

Acute Kidney Injury
Chapter:
Acute Kidney Injury
Author(s):

Suzanne M. Norby

and Kianoush B. Kashani

DOI:
10.1093/med/9780190464868.003.0049
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date: 19 October 2019

Simple acid-base disorders are defined by changes in pH and the initial change in 1 of the 2 variables, serum bicarbonate (HCO3-) and PCO2. Low pH indicates acidosis, and high pH indicates alkalosis. If 1 of the 2 components (HCO3-or PCO2) decreases, the other component also decreases (a compensatory change that minimizes the change in the ratio and the pH) and vice versa, as shown in the Henderson-Hasselbalch equation. Emphasis has been placed on the Henderson-Hasselbalch equation because the equation describes the 4 acid-base disorders and their compensatory changes.

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