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Malignant Hematologic Disorders 

Malignant Hematologic Disorders
Chapter:
Malignant Hematologic Disorders
Author(s):

Carrie A. Thompson

DOI:
10.1093/med/9780190464868.003.0039
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date: 19 October 2019

The 2 essential functions of the coagulation system (maintaining hemostasis and preventing and limiting thrombosis) are served by the procoagulant and anticoagulant components. Vascular injury results in activation of the phases of hemostasis, including vasospasm, platelet plug formation (platelet activation, adhesion, and aggregation), and fibrin clot formation (by activation of coagulation factors in the procoagulant system). The anticoagulant system controls excessive clot formation, while the fibrinolytic system breaks down and remodels blood clots.

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