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Gerald W. Volcheck

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date: 19 October 2019

Bronchial hyperresponsiveness and airway inflammation are common to all forms of asthma. Hyperresponsiveness is measured by assessing pulmonary function before and after exposure to albuterol, methacholine, histamine, cold air, or exercise. A decrease in forced expiratory volume in 1 second (FEV1) of 20% or more with challenge or an increase in FEV1 of 12% or more with albuterol is considered a sign of airway hyperreactivity. Patients who have chronic asthma and negative results on allergy skin tests usually have an inflammatory infiltrate in the bronchi and histologic findings dominated by eosinophils when asthma is active.

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