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Mazen O. Al-Qadi

, John C. O’Horo

, and Larry M. Baddour

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date: 16 January 2021

TSS is a severe, toxin-mediated illness that results from dysregulation of the host inflammatory response and is characterized by hypotension with multiorgan dysfunction. Although TSS was originally described as occurring in menstruating women, in more recent surveys 50% of cases occur in men and nonmenstruating women. Clinically, patients with TSS usually present with fever, severe myalgia, skin rash or diffuse erythema, hypotension, and multiorgan dysfunction.

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