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Severe Influenza A–Associated Acute Respiratory Distress Syndrome 

Severe Influenza A–Associated Acute Respiratory Distress Syndrome
Severe Influenza A–Associated Acute Respiratory Distress Syndrome

Rudy M. Tedja

and Craig E. Daniels

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date: 25 January 2021

Acute respiratory distress syndrome (ARDS) is a life-threatening respiratory condition characterized by diffuse inflammatory lung injury leading to profound hypoxemia and stiff lungs. It occurs typically within 6 to 72 hours after an inciting event. Influenza A viral pneumonia can progress to severe ARDS with multisystem organ failure, as seen during the 2009-2010 pandemic with H1N1 influenza A virus. Extensive studies on therapeutic modalities have found no effective pharmacologic therapies. Supportive care with mechanical ventilation remains the cornerstone of treatment.

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