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Brain Death 

Brain Death
Brain Death

Dereddi Raja S. Reddy

, Sudhir V. Datar

, and Eelco F. M. Wijdicks

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date: 25 July 2021

Deeply comatose patients who lose all clinical signs of brain function (including brainstem function) because of a major destructive lesion should be clearly distinguished from patients with other comatose states. When an untreatable catastrophic neurologic structural injury has been proved, irreversibility is determined by absent motor responses, loss of all brainstem reflexes, and apnea after a carbon dioxide challenge. Malignant ischemic infarction, intracerebral hemorrhage, severe traumatic brain injury, and aneurysmal subarachnoid hemorrhage are some of the common causes.

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