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Altered Mental Status and Rigidity 

Altered Mental Status and Rigidity
Altered Mental Status and Rigidity

Christopher L. Kramer

and Alejandro A. Rabinstein

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date: 28 January 2021

Neuroleptic malignant syndrome (NMS) is a rare but potentially lethal neurologic emergency associated with depletion of central nervous system dopamine from the use of antipsychotic medications or the sudden withdrawal of dopaminergic agents. Cardinal clinical features of the disorder include motor symptoms (predominantly rigidity), hypokinetic encephalopathy, hyperthermia, and dysautonomia. The rigidity can cause severe elevations in serum CK and rhabdomyolysis.

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