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A Paraneoplastic Syndrome 

A Paraneoplastic Syndrome
Chapter:
A Paraneoplastic Syndrome
Author(s):

Andres Borja Alvarez

and Emir Festic

DOI:
10.1093/med/9780190464813.003.0029
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date: 19 October 2019

Paraneoplastic neurologic syndromes (PNSs) are rare effects of cancer that are not caused by a tumor or its metastasis, an infection, or a metabolic process. PNS requires a high level of awareness because it can be the initial manifestation of a malignant process, and it can affect the nervous system at any level. The pathogenesis of PNS is related to an autoimmune response. The discovery of multiple antibodies led to the understanding that antigens in the nervous system can be abnormally expressed by a tumor. The role of each antibody has not been completely characterized, and the absence of antibodies does not rule out the diagnosis of PNS.

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