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Acute Renal Failure 

Acute Renal Failure
Chapter:
Acute Renal Failure
Author(s):

Mazen O. Al-Qadi

and Amy W. Williams

DOI:
10.1093/med/9780190464813.003.0027
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date: 21 October 2019

Tumor lysis syndrome (TLS) is a common emergency encountered in patients with hematologic malignancies. It is caused by the massive release of intracellular toxic metabolites when malignant tumor cells die (or by high rates of purine metabolism in spontaneous TLS). The syndrome develops within hours to days (up to 7 days) after initiation of chemotherapy and is characterized by hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia. If not treated promptly, these metabolic derangements may result in acute kidney injury, metabolic acidosis, arrhythmias, and death.

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