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More Than Meets the Eye 

More Than Meets the Eye
Chapter:
More Than Meets the Eye
Author(s):

Sumedh S. Hoskote

, Shivani S. Shinde

, and Nathan J. Smischney

DOI:
10.1093/med/9780190464813.003.0016
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date: 23 October 2019

The term hyperleukocytosis is generally used to define a total leukocyte count greater than 100´109/L or a blast cell count greater than 50´109/L. Hyperleukocytosis with concurrent symptoms of hyperviscosity or impaired tissue perfusion is termed leukostasis, which is an oncologic emergency. Leukostasis occurs most typically in a blast crisis associated with acute myeloid leukemia or chronic myeloid leukemia. Leukostasis is associated with a mortality rate of up to 30%, especially among elderly patients with poor performance status, coagulopathy, respiratory compromise, and multiorgan dysfunction.

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