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Genetics and Gene–Environment Interaction 

Genetics and Gene–Environment Interaction
Chapter:
Genetics and Gene–Environment Interaction
Author(s):

Torsten Klengel

, Lauren A. M. Lebois

, Sheila Gaynor

, and Guia Guffanti

DOI:
10.1093/med/9780190457136.003.0017
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date: 28 January 2022

Trauma and stress-related disorders make an excellent case for gene-environment interactions because although exposure to trauma and stress is a well-established risk factors toward their development, such factors alone are not sufficient to explain etiopathogenesis. Exposure to traumatic events is a prerequisite of posttraumatic stress disorder (PTSD) diagnosis, but the majority of individuals who are exposed to even a severe traumatic event do not develop PTSD. Why some individuals are vulnerable and others are resilient remains an open question. While genetic factors may play a significant role, it is conceivable that the complex interplay between genetic and environmental factors contribute to the observed interindividual variability.

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