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Preemptive, Preventive, and Multimodal Analgesia 

Preemptive, Preventive, and Multimodal Analgesia
Preemptive, Preventive, and Multimodal Analgesia

Daniel Chang

, Mia Castro

, Vineetha S. Ratnamma

, Alessandra Verzelloni

, Dionne Rudison

, and Nalini Vadivelu

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date: 03 December 2020

Preemptive analgesia focuses on postoperative pain control and the prevention of central sensitization and chronic neuropathic pain by providing analgesia administered preoperatively. Preventive analgesia reduces postoperative pain and consumption of analgesics, and this appears to be the most effective means of decreasing postoperative pain. Preventive analgesia, which includes multimodal preoperative and postoperative analgesic therapies, results in decreased postoperative pain and less postoperative consumption of analgesics. Several advances have been made in our understanding of pain signaling pathways, which have since enabled caregivers to treat pain using a multimodal (or “balanced”) approach to providing adequate pain relief while minimizing side effects. This allows for a reduction in the doses of individual drugs and thus a lower incidence of adverse effects from any particular medication used for analgesia.

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