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Unique Challenges Facing Immunotherapy of Metastatic Ovarian Cancer 

Unique Challenges Facing Immunotherapy of Metastatic Ovarian Cancer
Chapter:
Unique Challenges Facing Immunotherapy of Metastatic Ovarian Cancer
Author(s):

Michelle N. Messmer

, Colleen S. Netherby

, and Scott I. Abrams

DOI:
10.1093/med/9780190248208.003.0012
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date: 22 October 2019

The immune system serves as an integral checkpoint to developing malignancies. However, when cancer ultimately becomes detectable, this implicates an inherent failure of effective immune control. One constant theme in cancer biology has been the ability of these “diseases,” in particular, ovarian cancer, to compromise immune-mediated mechanisms of neoplastic control. These empirical observations have subsequently laid the scientific foundation to investigate ways in which the immune system can be reengaged as a powerful therapeutic weapon, singly or in combination with other modalities. This field has been coined “cancer immunotherapy” and, importantly, strong progress has been made to date to justify its feasibility and potential merit. This chapter focuses on the fundamental immunologic principles that have guided the development of the cancer immunotherapy concept, as well as details both the successes and the limitations of cancer immunotherapy in patients with metastatic ovarian cancer.

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