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Acute Hyperthermic Syndromes 

Acute Hyperthermic Syndromes
Chapter:
Acute Hyperthermic Syndromes
Author(s):

Philippe Couillard

and Eelco F. M. Wijdicks

DOI:
10.1093/med/9780190244927.003.0009
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date: 19 October 2019

A high core body temperature is a medical emergency. Neuronal mitochondria and plasma membranes are thought to experience protein changes at temperatures higher than 40°C and lead to brain damage or dysfunction. In hyperthermia, the thermoregulatory control mechanisms are impaired or overwhelmed, as opposed to fever, in which the hypothalamic set point is increased. Hyperthermia can be caused by conditions such as thyrotoxicosis, pheochromocytoma, or meningitis. Heat stroke is another important example of hyperthermia. Drugs that impair thermoregulation can also play a role and include amphetamines, cocaine, opiates, antihistamines, selective serotonin reuptake inhibitors, b-blockers, and diuretics. There are several acute hyperthermia syndromes.

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