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Atypical Parkinsonian Syndromes 

Atypical Parkinsonian Syndromes
Chapter:
Atypical Parkinsonian Syndromes
Author(s):

Jeremy K. Cutsforth-Gregory

, Bradley F. Boeve

, and Keith A. Josephs

DOI:
10.1093/med/9780190244927.003.0026
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date: 23 October 2019

The cardinal features of parkinsonism are represented in the mnemonic TRAP: tremor at rest, rigidity, akinesia and bradykinesia, and postural instability. The parkinsonian phenotype encompasses a broad range of clinical and pathologic disorders; the most common (about 55% of cases) is idiopathic (sporadic) Parkinson disease (PD). Rapid disease progression, poor initial response to dopaminergic therapy, or the early presence of certain other signs may suggest an atypical parkinsonian syndrome, sometimes called parkinsonism-plus syndrome. Multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD) are reviewed in this chapter.

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