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The Hippocampal Formation: Learning and Memory 

The Hippocampal Formation: Learning and Memory
Chapter:
The Hippocampal Formation: Learning and Memory
Author(s):

Per Brodal

DOI:
10.1093/med/9780190228958.003.0032
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date: 25 February 2021

Chapter 32 deals with the hippocampus and nearby areas in the parahippocampal gyrus (the dentate gyrus and the entorhinal area), together comprising the hippocampal formation. These structures play a crucial role for certain kinds of learning and memory. The hippocampal formation receives highly processed sensory information, and the hippocampal projection neurons send signals to several cortical areas and to the mammillary nucleus. Only the memory of events and facts (declarative memory) depends critically on the integrity of medial parts of the temporal lobe. The hippocampal formation is not the only part of the brain that is important for memory, however, and it appears to be important only for a certain time after an event. This is probably because, after a certain time, relevant synaptic changes are distributed in many parts of the cerebral cortex. Bilateral damage of the hippocampal formation leads to amnesia.

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