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Nutraceutical and Alternative Treatments for Obsessive-Compulsive and Related Disorders 

Nutraceutical and Alternative Treatments for Obsessive-Compulsive and Related Disorders
Chapter:
Nutraceutical and Alternative Treatments for Obsessive-Compulsive and Related Disorders
Author(s):

David A Camfield

, and Jerome Sarris

DOI:
10.1093/med/9780190228163.003.0044
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date: 26 June 2022

This chapter reviews current research regarding nutraceutical substances that have been systematically investigated through either case studies, open-label and/or randomized placebo-controlled trials and found to have some evidence of efficacy in the treatment of obsessive compulsive and related disorders (specifically, trichotillomania, compulsive nail biting, and excoriation). The substances to be considered are myo-inositol, St. John’s wort, milk thistle, borage, glycine, sarcosine, psilocybin, and N-acetylcysteine. A description of each substance is presented, together with relevant biochemistry and interpretation regarding the current evidence of efficacy and safety/tolerability as well as what can be determined about factors that may moderate its efficacy, including OCD symptom severity, and advice in regard to concomitant antidepressant use. Conclusions and recommendations for future research are also presented.

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