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Standard Evidence-Based Pharmacological Treatment for OCD 

Standard Evidence-Based Pharmacological Treatment for OCD
Standard Evidence-Based Pharmacological Treatment for OCD

Jemma E Reid

, Samar Reghunandanan

, Ann Roberts

, and Naomi A Fineberg

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date: 26 June 2022

This chapter reviews standard pharmacological treatments for OCD and the evidence supporting them. Selective serotonin reuptake inhibitors (SSRIs) remain the pharmacological treatment of choice and are associated with improved health-related quality of life. Improvements are usually sustained over time as long as treatment is continued. Discontinuation is associated with relapse and loss of quality of life, implying that treatment should continue long-term. A substantial minority of patients who fail to respond to SSRIs may benefit from dose elevation, switch to clomipramine, or adjunctive antipsychotic, though long-term trials validating the effectiveness and tolerability of these strategies are relatively lacking.

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