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Spontaneously Occurring Animal Models of OCD 

Spontaneously Occurring Animal Models of OCD
Chapter:
Spontaneously Occurring Animal Models of OCD
Author(s):

Nicholas H. Dodman

, and Louis Shuster

DOI:
10.1093/med/9780190228163.003.0032
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date: 26 June 2022

This chapter summarizes what we know about compulsive behavioral disorders in several animal species. Animals can develop repetitive behaviors in a range of circumstances, generally associated with anxiety or stress. It is increasingly apparent that these behaviors recapitulate core features of obsessive-compulsive disorder. They are clearly partially genetic; for example, specific breeds of dog are susceptible to specific compulsive behavioral disorders. Understanding such OCD-like behaviors provides a potentially fruitful avenue towards understanding OCD in humans. This chapter reviews this literature, emphasizing the points of parallelism between repetitive behavior syndromes in animals and human disease. Recent advances in our understanding of the biology of these spontaneously occurring animal models, especially in dogs, have great potential to elucidate the pathophysiology of OCD.

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