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PANDAS as a Poststreptococcal Autoimmune Neuropsychiatric Form of OCD 

PANDAS as a Poststreptococcal Autoimmune Neuropsychiatric Form of OCD
PANDAS as a Poststreptococcal Autoimmune Neuropsychiatric Form of OCD

Susan E. Swedo

, and Kyle A. Williams

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date: 26 June 2022

This chapter reviews evidence for an autoimmune etiology in a subset of pediatric OCD cases. The sudden onset of OCD and related symptoms following an infectious illness in youth has been termed Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus, or PANDAS. By analogy with the better-understood syndrome of Sydenham Chorea, it has been hypothesized (as the name implies) that this syndrome derives from the development of brain-reactive autoantibodies after infection. The specifics of this pathophysiology have been difficult to establish, and the syndrome remains somewhat controversial. Nevertheless, treatment with antibiotics and immune-modulating therapies has shown promise in these cases.

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