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Neuropeptides in OCD 

Neuropeptides in OCD
Chapter:
Neuropeptides in OCD
Author(s):

Anahid Kabasakalian

, and Eric Hollander

DOI:
10.1093/med/9780190228163.003.0026
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date: 26 June 2022

The chapter considers past investigations of neuropeptides and their dysregulation in obsessive-compulsive disorder (OCD) and related conditions, and future directions for study. It reviews how the diagnostic reclassification of OCD in DSM-5, the stress response, reward mechanisms, as well as neuropsychological, functional imaging and genetic studies contribute to understanding of the role that neuropeptides have played in OCD and related areas. Avenues of further investigation are considered in the context of novel endogenous neuropeptides, newly identified roles for established neuropeptides, and the greater understanding of interactions between neuropeptides both with other neuropeptides and with neurotransmitters.

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