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Serotonin Toxicity 

Serotonin Toxicity
Serotonin Toxicity

Patrick E. Britell

, and Charles M. Andrews

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date: 23 June 2021

Serotonin toxicity is a potentially life-threatening and severe illness that results from excess serotonin activity. It can be due to prescription medications, drug interactions, and sometimes intentional poisonings. This illness is often iatrogenic and can be predicted by the amount of excess serotonin (5-HT) that activates serotonin receptors both centrally and peripherally. Serotonin toxicity produces a large range of symptoms and varies in cases from mild to severe and even lethal. This chapter reviews the mechanism of development of this illness, symptoms and criteria for diagnosis, appropriate assessment of the patient in the clinical setting, and an outline for timely treatment.

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