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Opioid and Benzodiazepine Overdose 

Opioid and Benzodiazepine Overdose
Chapter:
Opioid and Benzodiazepine Overdose
Author(s):

Brad Eastman

, and Larry Field

DOI:
10.1093/med/9780190226459.003.0092
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date: 21 September 2020

This chapter, “Opioid and Benzodiazepine Overdose,” reviews the pathophysiology of disease state pertaining to overdose as well as the molecular mechanisms involved with drug receptor binding. It discusses common presenting signs and symptoms of opioid and benzodiazepine overdose in the context of a clinical scenario. It also discusses specific patient populations that are at increased risk of opioid and benzodiazepine overdose. Initial and subsequent treatment options are thoroughly examined while allowing the reader to engage in clinical discussions to open-ended questions provided throughout the chapter. The use of opioid and benzodiazepine antagonists as antidotes is reviewed in detail along with common doses and regimens.

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