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Coagulation System: Direct Oral Anticoagulants 

Coagulation System: Direct Oral Anticoagulants
Chapter:
Coagulation System: Direct Oral Anticoagulants
Author(s):

Christina F. Burger

, Melissa L. Bellomy

, and Joseph J. Schlesinger

DOI:
10.1093/med/9780190226459.003.0091
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date: 27 February 2020

Anticoagulation is increasingly prevalent in the general population and poses a significant risk of increased bleeding in patients needing urgent or emergent surgical procedures. There are two main classes of direct or anticoagulants: direct thrombin inhibitors and factor Xa inhibitors. Management of these patients requires assessment of bleeding risk, possible reversal of anticoagulation, and subsequent management after surgery to prevent postoperative complications associated with either bleeding or clot formation (due to cessation of anticoagulants). This chapter covers the proper assessment and management of patients on oral direct thrombin inhibitor or oral Factor Xa inhibitor therapies.

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