Show Summary Details
Page of

Local Anesthesia Systemic Toxicity 

Local Anesthesia Systemic Toxicity
Local Anesthesia Systemic Toxicity

Joel Barton

, and Gavin Martin

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 19 June 2021

Regional anesthesia can deliver multiple benefits to patients undergoing surgery. However, administering even appropriate doses of local anesthetic agents for regional anesthesia can be life threatening, and the risks must be well understood. Local anesthetic systemic toxicity (LAST) is a spectrum or sequence of symptoms and dysfunction that affects the nervous and cardiopulmonary systems. Management of LAST revolves around recognition, supportive care, and, specifically, administration of lipid emulsion. The American Society of Regional Anesthesia practice advisory for management of LAST is an excellent point-of-care reference for anesthesiologists practicing regional anesthesia.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.