Show Summary Details
Page of

Biomarkers for Initiation of Renal Replacement Therapy 

Biomarkers for Initiation of Renal Replacement Therapy
Chapter:
Biomarkers for Initiation of Renal Replacement Therapy
Author(s):

Alexander Zarbock

and Lakhmir S. Chawla

DOI:
10.1093/med/9780190225537.003.0007
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 20 October 2020

The diagnosis of acute kidney injury (AKI) is based on changes of serum creatinine and/or urine output. However, serum creatinine and urine output have a low sensitivity and specificity, respectively. Serum creatinine can be influenced by several factors (e.g. fluid therapy, muscle mass) and it does not accurately reflect kidney function (serum creatinine increases after more than 50% of the GFR is lost) and degree of tubular injury, whereas urine output can be influenced by diuretics and hypovolemia. In addition, both markers cannot predict whether the kidney function improves or deteriorates.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.