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Biomarkers for Initiation of Renal Replacement Therapy 

Biomarkers for Initiation of Renal Replacement Therapy
Biomarkers for Initiation of Renal Replacement Therapy

Alexander Zarbock

and Lakhmir S. Chawla

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date: 19 June 2021

The diagnosis of acute kidney injury (AKI) is based on changes of serum creatinine and/or urine output. However, serum creatinine and urine output have a low sensitivity and specificity, respectively. Serum creatinine can be influenced by several factors (e.g. fluid therapy, muscle mass) and it does not accurately reflect kidney function (serum creatinine increases after more than 50% of the GFR is lost) and degree of tubular injury, whereas urine output can be influenced by diuretics and hypovolemia. In addition, both markers cannot predict whether the kidney function improves or deteriorates.

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