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Basic Principles of Solute Transport 

Basic Principles of Solute Transport
Basic Principles of Solute Transport

Zhongping Huang

, Jeffrey J. Letteri

, Claudio Ronco

, and William R. Clark

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date: 27 July 2021

From a kinetic perspective, Figure 4.1 depicts the relevant flows for determining CRRT clearances while Table 4.1 provides the solute clearance expressions, which differ from those used in conventional hemodialysis. In the latter therapy, the mass removal rate (i.e., the rate at which the hemodialyzer extracts solute from blood into the dialysate) is estimated by measuring the difference in solute concentration between the arterial and venous lines. In other words, a “blood-side” clearance approach is used. On the other hand, in CRRT, the mass removal rate is estimated by measuring the actual amount of solute appearing in the effluent. The mass removal rate is the product of the effluent flow rate (QEFF) and the effluent concentration of the solute (CEFF).

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