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Dehua Gong

and Claudio Ronco

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date: 23 June 2021

Endotoxin: Endotoxin is a lipopolysaccharide (LPS), and an outer membrane molecule essential for virtually all Gram-negative bacteria. It is generally considered a major causative agent in Gram-negative bacteria infection-related shock state. LPS will bind to LPS-binding protein(LBP) and be transferred to bind to surface molecule CD14 when it enters into blood, presented in aggregate form or monomeric form. The signal of LPS combination with CD14 will be relayed by toll-like receptor(TCR) to activate the nuclear factor κ‎B(NF-κ‎B) and produce multiple cytokines.

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