Show Summary Details
Page of

MARS: Molecular Adsorbent Recirculating System 

MARS: Molecular Adsorbent Recirculating System
Chapter:
MARS: Molecular Adsorbent Recirculating System
Author(s):

Nigel Fealy

and Rinaldo Bellomo

DOI:
10.1093/med/9780190225537.003.0023
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 30 May 2020

Molecular Adsorbent Recirculating System (MARS) is an artificial liver support system aimed at the removal of toxins in patients suffering Acute Liver Failure (ALF) or Acute on Chronic Liver Failure (AoCLF). MARS is performed through an additional circuit attached to a standard extracorporeal circuit (continuous renal replacement circuit), which uses albumin as a dialysis medium. Using albumin as carrier molecule, toxins are then adsorbed on to specific sorbents. Most liver toxins such as bilirubin, ammonia, fatty acids, hydrophobic bile acids and nitric oxide, use albumin as their transport protein and, as a result, appear to be more effectively removed by an albumin-enriched dialysate. This albumin dialysate is re-generated on-line by passage through a second hemodialyser and two sorbent columns (charcoal and an anion exchanger).

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.