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MARS: Molecular Adsorbent Recirculating System 

MARS: Molecular Adsorbent Recirculating System
MARS: Molecular Adsorbent Recirculating System

Nigel Fealy

and Rinaldo Bellomo

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date: 23 June 2021

Molecular Adsorbent Recirculating System (MARS) is an artificial liver support system aimed at the removal of toxins in patients suffering Acute Liver Failure (ALF) or Acute on Chronic Liver Failure (AoCLF). MARS is performed through an additional circuit attached to a standard extracorporeal circuit (continuous renal replacement circuit), which uses albumin as a dialysis medium. Using albumin as carrier molecule, toxins are then adsorbed on to specific sorbents. Most liver toxins such as bilirubin, ammonia, fatty acids, hydrophobic bile acids and nitric oxide, use albumin as their transport protein and, as a result, appear to be more effectively removed by an albumin-enriched dialysate. This albumin dialysate is re-generated on-line by passage through a second hemodialyser and two sorbent columns (charcoal and an anion exchanger).

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