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Therapeutic Plasma Exchange in Critical Care Medicine 

Therapeutic Plasma Exchange in Critical Care Medicine
Therapeutic Plasma Exchange in Critical Care Medicine

Joseph E. Kiss

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date: 20 June 2021

Therapeutic plasma exchange (TPE) is the automated removal of a patient’s plasma and replacement (exchange) with a suitable alternative fluid such as a solution containing albumin or fresh frozen plasma. Its intended use is for depletion of pathogenic large molecular weight substances (>30-50,000 Daltons) present in blood plasma, and/or replacement of depleted normal/beneficial substances. Smaller molecular weight compounds are not efficiently removed by TPE, but may be effectively removed by alternative extracorporeal techniques such as hemofiltration (<20-30,000 Daltons) or dialysis (<500-600 Daltons).

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