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Regional Citrate Anticoagulation 

Regional Citrate Anticoagulation
Chapter:
Regional Citrate Anticoagulation
Author(s):

Nigel Fealy

DOI:
10.1093/med/9780190225537.003.0019
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date: 27 January 2021

When citrate is infused into the blood circuit, it combines with ionised calcium (IC) to form citrate – calcium complexes (non-ionised). This reduces the level of ionised calcium in the extracorporeal circuit, which in turn leads to the inhibition of clotting in the circuit. The target for circuit ionised serum calcium level to prevent or retard clotting is generally between 0.25 – 0.4 mmol/L.

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