- Dedication
- Preface
- Contributors
- Chapter 1 The Critically Ill Patient with Acute Kidney Injury
- Chapter 2 History and Rationale for Continuous Renal Replacement Therapy
- Chapter 3 Nomenclature for Renal Replacement Therapy in Acute Kidney Injury
- Chapter 4 Basic Principles of Solute Transport
- Chapter 5 Principles of Fluid Management in the Intensive Care Unit
- Chapter 6 Indications, Timing, and Patient Selection
- Chapter 7 Biomarkers for Initiation of Renal Replacement Therapy
- Chapter 8 Extended Indications
- Chapter 9 Dose Adequacy and Assessment
- Chapter 10 Acid–Base and Electrolyte Disorders
- Chapter 11 Choosing a Renal Replacement Therapy in Acute Kidney Injury
- Chapter 12 Vascular Access for Continuous Renal Replacement Therapy
- Chapter 13 The Circuit and the Prescription
- Chapter 14 The Membrane
- Chapter 15 Fluids for Continuous Renal Replacement Therapy
- Chapter 16 Alarms and Troubleshooting
- Chapter 17 Nonanticoagulation Strategies to Optimize Circuit Function in RRT
- Chapter 18 Anticoagulation
- Chapter 19 Regional Citrate Anticoagulation
- Chapter 20 Drug Dosing in Continuous Renal Replacement Therapy
- Chapter 21 Renal Replacement Therapy in Children
- Chapter 22 Therapeutic Plasma Exchange in Critical Care Medicine
- Chapter 23 MARS
- Chapter 24 Sorbents
- Chapter 25 Hybrid Therapies
- Chapter 26 The ICU Environment
- Chapter 27 Patient Care Quality and Teamwork
- Chapter 28 Organizational Aspects
- Chapter 29 Documentation, Billing, and Reimbursement for Continuous Renal Replacement Therapy
- Chapter 30 Machines for Continuous Renal Replacement Therapy
- Chapter 31 Quality Improvement for Continuous Renal Replacement Therapies
- Chapter 32 Educational Resources
- Glossary
- Index
(p. 151) Regional Citrate Anticoagulation
- Chapter:
- (p. 151) Regional Citrate Anticoagulation
- Author(s):
Nigel Fealy
- DOI:
- 10.1093/med/9780190225537.003.0019
When citrate is infused into the blood circuit, it combines with ionised calcium (IC) to form citrate – calcium complexes (non-ionised). This reduces the level of ionised calcium in the extracorporeal circuit, which in turn leads to the inhibition of clotting in the circuit. The target for circuit ionised serum calcium level to prevent or retard clotting is generally between 0.25 – 0.4 mmol/L.
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- Dedication
- Preface
- Contributors
- Chapter 1 The Critically Ill Patient with Acute Kidney Injury
- Chapter 2 History and Rationale for Continuous Renal Replacement Therapy
- Chapter 3 Nomenclature for Renal Replacement Therapy in Acute Kidney Injury
- Chapter 4 Basic Principles of Solute Transport
- Chapter 5 Principles of Fluid Management in the Intensive Care Unit
- Chapter 6 Indications, Timing, and Patient Selection
- Chapter 7 Biomarkers for Initiation of Renal Replacement Therapy
- Chapter 8 Extended Indications
- Chapter 9 Dose Adequacy and Assessment
- Chapter 10 Acid–Base and Electrolyte Disorders
- Chapter 11 Choosing a Renal Replacement Therapy in Acute Kidney Injury
- Chapter 12 Vascular Access for Continuous Renal Replacement Therapy
- Chapter 13 The Circuit and the Prescription
- Chapter 14 The Membrane
- Chapter 15 Fluids for Continuous Renal Replacement Therapy
- Chapter 16 Alarms and Troubleshooting
- Chapter 17 Nonanticoagulation Strategies to Optimize Circuit Function in RRT
- Chapter 18 Anticoagulation
- Chapter 19 Regional Citrate Anticoagulation
- Chapter 20 Drug Dosing in Continuous Renal Replacement Therapy
- Chapter 21 Renal Replacement Therapy in Children
- Chapter 22 Therapeutic Plasma Exchange in Critical Care Medicine
- Chapter 23 MARS
- Chapter 24 Sorbents
- Chapter 25 Hybrid Therapies
- Chapter 26 The ICU Environment
- Chapter 27 Patient Care Quality and Teamwork
- Chapter 28 Organizational Aspects
- Chapter 29 Documentation, Billing, and Reimbursement for Continuous Renal Replacement Therapy
- Chapter 30 Machines for Continuous Renal Replacement Therapy
- Chapter 31 Quality Improvement for Continuous Renal Replacement Therapies
- Chapter 32 Educational Resources
- Glossary
- Index