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Fluids for Continuous Renal Replacement Therapy 

Fluids for Continuous Renal Replacement Therapy
Fluids for Continuous Renal Replacement Therapy

Paul M. Palevsky

and John A. Kellum

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date: 20 June 2021

Considerable variability exists in the prescription of dialysate and replacement fluids for continuous renal replacement therapy (CRRT). In general, the electrolyte composition of these fluids should resemble the physiologic composition of plasma water, albeit sometimes with lower potassium and slightly higher buffer content in order to permit correction of hyperkalemia and metabolic acidosis. Intravenous replacement fluids must be sterile and pyrogen-free. Although dialysate does not need to meet the same standards for sterility, commercially manufactured dialysate for CRRT must be bacteriologically sterile in order to have a viable shelf-life.

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