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The Membrane: Size and Material 

The Membrane: Size and Material
The Membrane: Size and Material

Zhongping Huang

, Jeffrey J. Letteri

, Claudio Ronco

, and William R. Clark

Page of

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date: 27 July 2021

As opposed to chronic hemodialysis, for which cellulosic membranes continue to be used commonly, membrane comprising CRRT filters are almost exclusively synthetic. Synthetic membranes were developed essentially in response to concerns related to the narrow scope of solute removal and the pronounced complement activation associated with unmodified cellulosic filters. The AN69® membrane, a copolymer of acrylonitrile and an anionic sulfonate group, was first employed in flat sheet form in a closed-loop dialysate system in the early 1970’s for chronic hemodialysis. Since that time, a number of other synthetic membranes have been developed, including polysulfone, polyamide, polymethylmethacrylate, polyethersulfone, and polyarylethersulfone/polyamide. As is the case in chronic hemodialysis, all of these membranes either have been used or currently are being used in a CRRT application.

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