Show Summary Details
Page of

The Circuit and the Prescription 

The Circuit and the Prescription
Chapter:
The Circuit and the Prescription
Author(s):

Rinaldo Bellomo

and Ian Baldwin

DOI:
10.1093/med/9780190225537.003.0013
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 30 May 2020

There is no evidence to suggest that choosing CRRT based on hemofiltration over hemodiafiltration or over hemodialysis leads to clinically important differences in outcomes. There is a clear difference, however, in terms of the nature of solute removal with convection (filtration) leading to essentially equal small solute removal but much greater middle molecular weight solute removal. It is unclear, however, whether this effect matters pathophysiologically or clinically. Because of such uncertainty, physicians and nurses choose a particular approach in a given unit (typically based on local tradition, comfort, ease of operation etc.) and apply it consistently to all patients. Epidemiological data suggest that continuous veno-venous hemodiafiltration (CVVHDF) with replacement fluid delivered in pre-dilution mode may be the most common approach to CRRT worldwide, followed by continuous veno-venous hemofiltration (CVVH) also with pre-dilution.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.