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National CT Colonography Trial: The ACRIN 6664 Trial 

National CT Colonography Trial: The ACRIN 6664 Trial
Chapter:
National CT Colonography Trial: The ACRIN 6664 Trial
Author(s):

Christoph I. Lee

DOI:
10.1093/med/9780190223700.003.0047
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date: 18 October 2019

This chapter, found in the cancer screening and management section of the book, provides a succinct synopsis of a key study examining the national trial on computed tomography (CT) colonography for colorectal cancer screening. This summary outlines the study methodology and design, major results, limitations and criticisms, related studies and additional information, and clinical implications. In this trial, CT colonography identified 90% of participants with adenomas or cancers measuring 10 mm or more in size. Results provide more evidence for CT colonography as an effective screening tool among asymptomatic average-risk individuals, but CT colonography does have lower sensitivity for smaller colorectal lesions (6–9 mm). In addition to outlining the most salient features of the study, a clinical vignette and imaging example are included in order to provide relevant clinical context.

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