Show Summary Details
Page of

Bioinformatics in Psychiatric Genetics 

Bioinformatics in Psychiatric Genetics
Chapter:
Bioinformatics in Psychiatric Genetics
Author(s):

Nikola S. Mueller

, Ivan Kondofersky

, Gökcen Eraslan

, Karolina Worf

, and Fabian J. Theis

DOI:
10.1093/med/9780190221973.003.0009
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 20 May 2019

Bioinformatics in psychiatric research is surveyed by exploring data analysis techniques tailored to extract information from genetic studies. Genome-wide association studies (GWAS) play a major role by providing links between certain psychiatric diseases and single-nucleotide polymorphisms (SNPs). A challenge in identifying such links is prioritizing SNPs, and we give an overview of state-of-the-art prioritization methods and discuss current trends. Furthermore, we give details on post-GWAS analysis by introducing network-based knowledge. The aim of incorporating network information either in the sense of local proximity or similar function, is the formulation of multivariate models where multiple SNPs may have synergistic effects on a disease that cannot be inferred univariately. Finally, we provide a list of a combination of available tools and biological databases of identified genetic associations to psychiatric diseases. These open up the possibility for researchers to use published results and thus profit from findings in their respective fields.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.