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Imaging Genetics 

Imaging Genetics
Chapter:
Imaging Genetics
Author(s):

Luanna Dixson

, Heike Tost

, and Andreas Meyer-Lindenberg

DOI:
10.1093/med/9780190221973.003.0008
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date: 20 November 2019

Imaging genetics is the study of how modifications of the DNA sequence may manifest in altered brain structure, function, and biochemistry. This field has been made possible through the combined analysis of genotyping and neuroimaging data in the same individual. Imaging genetics has had an especially significant impact in the realm of psychiatry, where the identification of genetic variants associated with heritable “intermediate phenotypes” provides important clues about underlying molecular mechanisms. More recently, integration of information on biological pathways, protein interactions, epigenetic factors, and gene expression has provided a holistic framework for developing biologically driven hypotheses of gene effects in the brain. This chapter gives a historical perspective on the imaging genetics approach, outlines a few key examples, and speculates on future directions for this exciting discipline.

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