Show Summary Details
Page of

Next-Generation Sequencing in Genetic Studies of Psychiatric Disorders 

Next-Generation Sequencing in Genetic Studies of Psychiatric Disorders
Chapter:
Next-Generation Sequencing in Genetic Studies of Psychiatric Disorders
Author(s):

Shweta Ramdas

and Jun Z. Li

DOI:
10.1093/med/9780190221973.003.0015
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 20 November 2019

Next-generation sequencing (NGS) technologies make it possible to efficiently detect DNA variants in either entire genomes or any subsets of the genome, and have dramatically enhanced our ability to search for genetic risk factors of complex psychiatric diseases. While genotyping-based association studies focus on common variants that track extended genomic segments, NGS provides unbiased identification of both common and rare variants, including those that are functionally important but appear in very few families or sporadic cases. Thus NGS directly highlights plausible causal variants, even if such variants are extremely heterogeneous in the population. Meanwhile, such heterogeneity requires new analytical approaches that can aggregate rare variant burden over predefined functional unit such as a gene or a segment of non-coding region with presumed function. Rapid application of NGS technologies also underscored other limits in psychiatric genetics research, including the need for detailed phenotyping and multi-scale integration of diverse data types.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.